As the understanding of the wrinkle formation process continues to advance so does our ability to impede this process. Wrinkles and their formation due to facial expressions, repetitive motions, environmental damage, and natural aging are no longer considered uncorrectable. Wrinkles have been proven to be preventable and reversible.

Expression and repetitive motion wrinkles form because of lingering skin tension produced when excessive chemical signals stimulate facial muscles. These types of wrinkles can form each time you smile, frown, laugh or cry. Repetitive movements can even occur while you are asleep. Over time this results in: brow lines (11s), forehead creases, crow’s feet, laugh lines, lip lines around the mouth, and overall aging in the appearance of the skin.

The cause of skin tension and muscle contractions that form wrinkles relies on a delicate neurotransmitter process called the SNARE complex. The SNARE complex involves three proteins (Snap 25, Vamp, and Syntaxin) that combine to allow neurons to complete exocytosis. Exocytosis is the release of chemicals across the neuron’s synapse that triggers the contraction of a muscle. Preventing or interrupting this exocytosis is the key to stopping or attenuating muscle contractions and hence relaxing existing wrinkles and preventing new ones from forming. Botulinum Toxin (BOTOX®) targets and stops this same process.


DermaExcel 7 treats wrinkles by combining the three most advanced peptides
DermaExcel 7 is the first anti-wrinkle product to combine the three latest cutting-edge peptides in a single spot wrinkle treatment. DermaExcel 7 contains 5% PentaPeptide (Leuphasyl), 10% Acetyl HexaPeptide (Argireline), and 10% HeptaPeptide (Snap-7), a Janson Beckett first. Each peptide interrupts the wrinkle producing SNARE complex differently but produces similar and collaborative results – Reduced depth of wrinkles and younger looking skin.

The PentaPeptide Leuphasyl works outside the pre-synaptic neuron and prior to Argireline or Snap-7. The body carries a slight electrical charge. When the repetitive movements occur, the electrical charge in that part of the body rises. Leuphasyl helps moderate the release of acetylcholine during the SNARE complex by lowering the skin’s electrical charge in the applied area, making it more difficult for neurons to fire. Since neurons move the muscles by delivering acetylcholine into the muscle cells, Leuphasyl’s ability to moderate the electrical charge being sent to the applied area is crucial in lessening and relaxing muscle contraction. Impairing muscle contraction is what makes the skin look younger and mitigates wrinkles and their formation.

Acteyl HexaPeptide (Argireline) is a popular ingredient in wrinkle cosmetics and was the first peptide to offer effects similar to BOTOX. Argireline works by mimicking a component of the SNARE complex to block the nerve signals and by inhibiting the overproduction of catecholamines. By blocking these neurotransmitters, Argireline reduces the contraction of muscles and reduces wrinkles and prevents wrinkle formation.

HeptaPeptide (Snap-7) is a natural amino acid that contains seven amino peptides. Snap-7’s advanced peptide structure is more efficient at stopping vesicle formation and neurotransmitter release than any other amino peptide. Snap-7 is essentially the next level of amino peptide that works faster and reduces deeper wrinkles that the others could not. Snap-7 accomplishes this by binding to existing Snap-25 receptors to block the release of acetylcholine. This prevents neurons from effectively transmitting signals that instruct muscles to contract. When repetitive movements are impaired, the formation of fine lines and wrinkles is reduced or prevented.

The complementary system of Leuphasyl, Argireline and Snap-7 makes DermaExcel 7’s formula even more effective. Because Leuphasyl lowers local synaptic voltage, neuron responsiveness and efficiency is lowered. Argireline and Snap-7 then work in concert to intercept any neurotransmitters actually released. This combined method of treatment prevents and lessens muscle contractions, subsequently reducing repetitive or expressive wrinkle formation.


DermaExcel 7 combats your deep wrinkles and augments the effects of AlphaDerma CE
DermaExcel 7’s formula is an evolutionary step in spot wrinkle prevention and repair targeted at eliminating the final deep wrinkles that resist AlphaDerma CE. By combining three cutting-edge peptides, along with Alpha Lipoic Acid, a powerful antioxidant, DMAE, a skin firmer, and Shea Butter, a superior skin moisturizer, Janson Beckett continues a multi-faceted approach to anti-wrinkle and anti-aging skin care.

Similar to its sibling AlphaDerma CE, DermaExcel 7 can produce results immediately. Test subjects reported seeing quick improvements and commented they felt their skin tighten and pleasantly tingle for up to 30 minutes after application. AlphaDerma CE revolutionized wrinkle creams, and now DermaExcel 7 is ready to safely but aggressively eradicate your last stubborn or hard-to-remove wrinkles. Although DermaExcel 7 is a great stand-alone product for wrinkles, the AlphaDerma CE sets the skin’s proper balance to further increase the absorption and benefits of the DermaExcel 7.

Directions for stand-alone or with AlphaDerma CE use:
1. Cleanse application area with warm water and cleanser (we suggest using Janson Beckett’s Organic Cleansing Milk)
2. Apply DermaExcel 7 to hard to remove wrinkle areas. For best results, use in combination with and after applying AlphaDerma CE.

When adding DermaExcel 7 to Janson Beckett’s anti-aging skin care regimen:
1. Cleanse application area with warm water using Organic Cleansing Milk.
2. Apply Skin Toner sparingly to hands and pat into face and throat. Let dry.
3. Apply AH3 HexaPeptide Facial Skin Prep and let dry.
4. Place a few drops of Vitamin C&C Facial Serum on finger tips and pat gently around eyes, forehead, cheeks, or wherever necessary. Let dry.
5. Gently massage AlphaDerma CE into desired area. Allow to absorb.
6. Apply DermaExcel 7 to hard to remove wrinkle areas. Allow to absorb.
7. Optionally, apply a couple drops of OkuSil to finger tips and pat lightly from the bridge of nose outward under the eye area and above the eye under the brow.

INGREDIENTS: Demineralized spring water, olive oil, argireline (AH3 acetyl hexapeptide), snap 7 heptapeptide, glycerine, pentapeptides - 3, cetearyl alcohol, ceteareth 20, shea butter, soybean oil, alpha lipoic acid, milk thistle extract, DMAE bitartrate, allantoin, hydrolyzed soy protein, citric acid, carbomer 940, simethicone, caprylyl glycol, phenoxyethanol, methylparaben, propylparaben, ethylparaben, butylparaben, isobutylparaben, triethanolamine